AMME4971: Tissue Engineering (2014 - Semester 1)

Download UoS Outline

Unit: AMME4971: Tissue Engineering (6 CP)
Mode: Normal-Day
On Offer: Yes
Level: Senior Advanced
Faculty/School: School of Aerospace, Mechanical & Mechatronic Engineering
Unit Coordinator/s: A/Prof Zreiqat , Hala
Session options: Semester 1
Versions for this Unit:
Campus: Camperdown/Darlington
Pre-Requisites: None.
Brief Handbook Description: Core Unit of Study: With the severe worldwide shortage of donor organs and the ubiquitous problem of donor organ rejection, there is a strong need for developing technologies for engineering replacement organs and other body parts. Recent developments in biochemistry and cell biology have begun to make this possible, and as a consequence, the very new field of tissue engineering has been making dramatic progress in the last few years.

This UoS will provide an introduction to the principles of tissue engineering, as well as an up to date overview of recent progress in the field of tissue engineering is and where it is going. This UoS assumes prior knowledge of cell biology and chemistry and builds on that foundation to elaborate on the important aspects of tissue engineering. The objectives are:

1. To gain a basic understanding of the major areas of interest in tissue engineering

2. To learn to apply basic engineering principles to tissue engineering systems

3. To understand the challenges and difficulties of tissue engineering.

4. Understand the ethical issues of stem cell applications.

5. Practical classes in the preparation and evaluation of scaffolds for tissue regeneration.

6. Enable student to access web-based resources in tissue engineering (for example: Harvard-MIT Principles and Practice of Tissue Engineering).

7. Research basic skills in Tissue Engineering.
Assumed Knowledge: 6 credit points of junior biology,6 credit points of junior chemistry and 6 credit points of intermediate physiology or equivalent.
Additional Notes: The primary teaching delivery method will be lectures. This UoS builds on the assumed knowledge of junior and intermediate biology and thus students will already have practical hands-on biological training. The purpose of this UoS is to elaborate the theory and latest developments of this very new field of tissue engineering, thereby building on the existing practical and theoretical knowledge base the students have in cell biology.
Lecturer/s: A/Prof Zreiqat , Hala
Timetable: AMME4971 Timetable
Time Commitment:
# Activity Name Hours per Week Sessions per Week Weeks per Semester
1 Lecture 2.00 1 13
2 Tutorial 2.00 1 12
T&L Activities: Tutorial: Tutorial

Attributes listed here represent the key course goals (see Course Map tab) designated for this unit. The list below describes how these attributes are developed through practice in the unit. See Learning Outcomes and Assessment tabs for details of how these attributes are assessed.

Attribute Development Method Attribute Developed
The students will be required to submit an assignment on a topic of their choice from one of the lectures. The students will be expected to identify a problem in the related field and discuss ways of providing tissue engineering solutions. Design (Level 3)
The students will be given lectures in specific areas of tissue engineering by leading experts in the their area of research. This will give the students a broad knowledge on the latest developments in Tissue Engineering. Engineering/IT Specialisation (Level 3)
Information literacy. This will be developed through the group project activities. Literature survey of the latest research in the area of tissue engineering Information Seeking (Level 2)
Communication. This will be developed through the scheduled seminars. Students will be divided into small groups and assigned a paper/project and then present and discuss their findings and outcomes with the whole class Communication (Level 2)
Experience through the group project tutorial program will provide training in team work, communication and presentation skills. Professional Conduct (Level 2)

For explanation of attributes and levels see Engineering & IT Graduate Outcomes Table.

Learning outcomes are the key abilities and knowledge that will be assessed in this unit. They are listed according to the course goal supported by each. See Assessment Tab for details how each outcome is assessed.

Design (Level 3)
1. The students will each complete an individual assignment on the applications of tissue engineering to ophthalmology, dental, skeletal tissue, skin, neural, vascular and cardiology. In their assignment they will discuss the advances and future direction and identify key areas of shortcoming in the specific fields and discuss the general problem and possible solutions
Engineering/IT Specialisation (Level 3)
2. To develop a theoretical understanding of the basic concepts of tissue engineering and be exposed to the various specific disciplines of this field. The students will develop specific expertise through the lectures given by invited speakers at the forefront of their research.
Information Seeking (Level 2)
3. Students will gain expertise by conducting a scientific literature review of the current progress in the field of tissue engineering in general. Specifically, they will undertake a thorough scientific search on the latest development in the research conducted in their chosen assignment topic.
Communication (Level 2)
4. To achieve effective communications the class will be divided into small groups where each group will present their findings on their assigned project/paper for discussion with the whole class on their results, ideas and critically evaluate their scientific findings
Professional Conduct (Level 2)
5. Team work skills will be developed by participating in group tutorial projects. Each group will then discuss the assigned paper/project in detail, decide on key points and then report back to the entire class
Assessment Methods:
# Name Group Weight Due Week Outcomes
1 Final Exam No 40.00 Exam Period 1, 2, 3,
2 Assignment No 30.00 Week 12 1, 2, 3, 4, 5,
3 Presentation/Seminar Yes 30.00 Week 10 2, 3, 4, 5,
Assessment Description: Final Exam: Final 2 hour open-book exam

Assignment: Assignment on a tissue engineering topic. The assignment is due on Thursday week 13.
Grading:
Grade Type Description
Standards Based Assessment Final grades in this unit are awarded at levels of HD for High Distinction, DI (previously D) for Distinction, CR for Credit, PS (previously P) for Pass and FA (previously F) for Fail as defined by University of Sydney Assessment Policy. Details of the Assessment Policy are available on the Policies website at http://sydney.edu.au/policies . Standards for grades in individual assessment tasks and the summative method for obtaining a final mark in the unit will be set out in a marking guide supplied by the unit coordinator.
Policies & Procedures: Academic Honesty in Coursework. All students must submit a cover sheet for all assessment work that declares that the work is original and not plagiarised from the work of others.

Coursework assessment and examination policy. The faculty policy is to use standards based assessment for units where grades are returned and criteria based assessment for Pass/Fail only units. Norm referenced assessment will only be used in exceptional circumstances and its use will need to be justified to the Undergraduate Studies Committee. Special consideration for illness or misadventure may be considered when an assessment component is severely affected. This policy gives the details of the information that is required to be submitted along with the appropriate procedures and forms.

Special Arrangements for Examination and Assessment. In exceptional circumstances alternate arrangements for exams or assessment can be made. However concessions for outside work arrangements, holidays and travel, sporting and entertainment events will not normally be given.

Student Appeals against Academic Decisions. Students have the right to appeal any academic decision made by a school or the faculty. The appeal must follow the appropriate procedure so that a fair hearing is obtained.

Note that policies regarding assessment submission, penalties and assessment feedback depend upon the individual unit of study. Details of these policies, where applicable, will be found above with other assessment details in this unit outline.

All university policies can be found at http://sydney.edu.au/policy

Various request forms for the Faculty of Engineering and IT can be found at http://sydney.edu.au/engineering/forms/

Note that the "Weeks" referred to in this Schedule are those of the official university semester calendar https://web.timetable.usyd.edu.au/calendar.jsp

Week Description
Week 1 Overview of Tissue Engineering
Week 2 ISLET TRANSPLANTATION AND DENDRITIC CELL , for renal transplantation
Week 3 Engineering stem cells: from niche to clinic
Week 4 STEM CELLS: Future Therapeutic Prospects of Adult Stem Cells
Week 5 Regenerative Whole Organ Engineering
Week 6 Stem Cell Biology & Regenerative Medicine: Everything you've always wanted to know and was afraid to ask
Week 7 Extracellular matrix-Cartilage and Tendon regeneration
Week 8 Intravascular Scaffolding Using Coronary Stents. Past, Present, Future
Week 9 Embryonic stem cells
Week 10 Building bone with biologics
Assessment Due: Presentation/Seminar
Week 11 Dental implants pros and cons-need for bone regeneration in dentistry
Week 12 Building bone with Synthetic Materials
Assessment Due: Assignment
Week 13 Biomedical engineers and their practical approach to novel engineered synthetic bio-substitutes
Exam Period Assessment Due: Final Exam

Course Relations

The following is a list of courses which have added this Unit to their structure.

Course Year(s) Offered
Biomedical Engineering / Law 2013, 2014
Biomedical Engineering / Arts 2013, 2014
Biomedical Engineering / Commerce 2013, 2014
Biomedical Engineering / Medical Science 2013, 2014
Biomedical Engineering / Project Management 2013, 2014
Biomedical Engineering / Science 2013, 2014
Biomedical - Chemical and Biomolecular Major 2013, 2014, 2015, 2015
Biomedical - Electrical Major 2013, 2014, 2015
Biomedical - Information Technology Major 2013, 2014, 2015, 2015
Biomedical - Mechanical Major 2013, 2014, 2015, 2015
Biomedical - Mechatronics Major 2013, 2014, 2015, 2015
Biomedical /Science 2015
Biomedical - Electrical Major 2015
Mechanical (Biomedical) 2010, 2011, 2012
Mechanical Engineering (Biomedical) / Medical Science 2010, 2011, 2012
Mechanical Engineering (Biomedical) / Arts 2011, 2012
Mechanical Engineering (Biomedical) / Commerce 2012
Mechanical Engineering (Biomedical) / Project Management 2012
Mechanical Engineering (Biomedical) / Science 2011, 2012
Mechanical Engineering (Biomedical) / Law 2012

Course Goals

This unit contributes to the achievement of the following course goals:

Attribute Practiced Assessed
Project and Team Skills (Level 3) No 0%
Design (Level 3) Yes 19.33%
Engineering/IT Specialisation (Level 3) Yes 26.83%
Information Seeking (Level 2) Yes 26.83%
Communication (Level 2) Yes 13.5%
Professional Conduct (Level 2) Yes 13.5%

These goals are selected from Engineering & IT Graduate Outcomes Table which defines overall goals for courses where this unit is primarily offered. See Engineering & IT Graduate Outcomes Table for details of the attributes and levels to be developed in the course as a whole. Percentage figures alongside each course goal provide a rough indication of their relative weighting in assessment for this unit. Note that not all goals are necessarily part of assessment. Some may be more about practice activity. See Learning outcomes for details of what is assessed in relation to each goal and Assessment for details of how the outcome is assessed. See Attributes for details of practice provided for each goal.