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BMET5931: Nanomaterials in Medicine (2019 - Semester 1)

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Unit: BMET5931: Nanomaterials in Medicine (6 CP)
Mode: Normal-Day
On Offer: Yes
Level: Postgraduate
Faculty/School: School of Aerospace, Mechanical & Mechatronic Engineering
Unit Coordinator/s: Dr No, Young
Singh, Gurvinder
Professor Zreiqat, Hala
Session options: Semester 1
Versions for this Unit:
Campus: Camperdown/Darlington
Pre-Requisites: None.
Prohibitions: AMME5931.
Brief Handbook Description: The application of science and technology at the nanoscale for biomedical problems promises to revolutionise medicine. Recent years have witnessed unprecedented advances in the diagnosis and treatment of diseases by applying nanotechnology to medicine. This course focuses on explaining the fundamentals of nanomedicine, and highlighting the special properties and application of nanomaterials in medicine. This course also reviews the most significant biomedical applications of nanomaterials including the recent breakthroughs in drug delivery, medical imaging, gene therapy, biosensors and cancer treatment.

The aims and objectives of this unit of study are:

* To introduce the student to the application of nanotechnology in medicine and diverse range of nanomaterials used in this field.

* To give the student an overview of basic principles on synthesis and characterisation of nanomaterials in medicine.

* To enable students to understand the current challenges and difficulties in nanomedicine and give them ideas to engineer and design new materials to address the current challenges.

* To introduce students to the future impact of nanomedicine on healthcare practice.
Assumed Knowledge: 1000-level Biology and Chemistry; 3000-level or higher Engineering Design Practice and Biomedical Engineering; AMME1362 or 6cp 1000-level Materials Science; MECH2901 or BMET2901 or AMME9901 or BMET9901 or 2000-level Anatomy and Physiology.
Timetable: BMET5931 Timetable
Time Commitment:
# Activity Name Hours per Week Sessions per Week Weeks per Semester
1 Lecture 2.00 1 13
2 Tutorial 2.00 1 12

Attributes listed here represent the key course goals (see Course Map tab) designated for this unit. The list below describes how these attributes are developed through practice in the unit. See Learning Outcomes and Assessment tabs for details of how these attributes are assessed.

Attribute Development Method Attribute Developed
The students will be given lectures in specific areas of nanomedicine and they can be familiarise how to integrate engineering principles in nanomedicine. (2) Engineering/ IT Specialisation (Level 3)
The students will be required to submit an assignment whereby they will write a novel research project description. The content will be inspired by the lectures and individual reading. The students will be expected to identify a problem in the related field and discuss innovative and inventive ways of providing solutions. (3) Problem Solving and Inventiveness (Level 3)
The students will be required to submit an assignment whereby they will write a novel research project description. The content will be inspired by the lectures and individual reading. Their solution should take into account important practical considerations such as technical feasibility, surgical considerations, regulation and ethics. (4) Design (Level 3)
The nature of the content in this course draws from multiple fields of science and engineering - materials science, cell biology, anatomy and physiology, chemistry, regulatory affairs and ethics, physics, medical sciences. Students will be able to bring these concepts together and apply these in the context of nanomaterials in medicine. (5) Interdisciplinary, Inclusiveness, Influence (Level 3)
Inquiry/research will be developed through both the individual presentation and the group project activities. Both these assessments require students to access and analyze recent scientific developments published in the academic domain.

Both oral communication through individual presentations, and written and inter-member communication skills through group assessment will be developed.
(6) Communication and Inquiry/ Research (Level 2)
Students will be divided into small groups and will be tasked to write up a section of a research proposal application. This will require teamwork, time management skills, and task delegation skills.
Students will also employ ethical conduct during their research and information gathering process.
(8) Professional Effectiveness and Ethical Conduct (Level 2)

For explanation of attributes and levels see Engineering & IT Graduate Outcomes Table 2018.

Learning outcomes are the key abilities and knowledge that will be assessed in this unit. They are listed according to the course goal supported by each. See Assessment Tab for details how each outcome is assessed.

(2) Engineering/ IT Specialisation (Level 3)
1. Discuss the current state and recent developments in the field of nanomaterials in medicine
2. Apply and integrate engineering principles to nanomedicine
(3) Problem Solving and Inventiveness (Level 3)
3. Evaluate and assess the current challenges in nanomedicine
4. Create novel nanomaterial-based solutions to address current unmet clinical needs or to address limitations of current solutions
(4) Design (Level 3)
5. Formulate new designs for nanoscale materials to address unmet needs in the biomedical sector
6. Devise solutions taking financial and technical feasibility, as well as surgical considerations into account when designing solutions
(5) Interdisciplinary, Inclusiveness, Influence (Level 3)
7. Appreciate and recognize the interdisciplinary nature of the field of nanomedicine, whereby concepts from a wide range of areas including materials science, human biology, chemistry and physics are brought together.
(6) Communication and Inquiry/ Research (Level 2)
8. Employ techniques for effective oral and written communication of the concepts and knowledge underlining the background science and engineering applications of nanomaterials in medicine.
9. Identify, obtain, and analyze information using appropriate search strategies to gain in-depth knowledge and current advances in nanomaterials used in medicine.
(8) Professional Effectiveness and Ethical Conduct (Level 2)
10. Employ professional techniques and activities such as assigning tasks, managing time, meeting deadlines, and communicating with their colleagues in a professional manner.
Assessment Methods:
# Name Group Weight Due Week Outcomes
1 Assignment * Yes 40.00 Week 13 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,
2 Presentation * No 30.00 Week 7 1, 3, 7, 8, 9,
3 Final examination No 20.00 Exam Period 1, 2, 3, 7, 9,
4 Weekly Quizzes No 10.00 Multiple Weeks 1, 2, 3, 7, 9,
Assessment Description: * Students who miss assessment and have been granted special consideration will be awarded a replacement assessment or extension.

40% - Major Written Group Assessment (Handed out Week 3, Due Week 13)

30% - Individual Presentation Assessment (Handed out week 2, due Week 6)

20% - Final examination

10% - Short quiz every week (roughly 10 quizzes, 1% each), also includes attendance
Grading:
Grade Type Description
Standards Based Assessment Final grades in this unit are awarded at levels of HD for High Distinction, DI (previously D) for Distinction, CR for Credit, PS (previously P) for Pass and FA (previously F) for Fail as defined by University of Sydney Assessment Policy. Details of the Assessment Policy are available on the Policies website at http://sydney.edu.au/policies . Standards for grades in individual assessment tasks and the summative method for obtaining a final mark in the unit will be set out in a marking guide supplied by the unit coordinator.
Policies & Procedures: See the policies page of the faculty website at http://sydney.edu.au/engineering/student-policies/ for information regarding university policies and local provisions and procedures within the Faculty of Engineering and Information Technologies.

Note that the "Weeks" referred to in this Schedule are those of the official university semester calendar https://web.timetable.usyd.edu.au/calendar.jsp

Week Description
Week 1 Introduction to nanomaterials in medicine
Week 2 Basic nanomaterial-cell interactions and nanotoxicity
Week 3 Liposomes for biomedical applications
Week 4 Synthesis and characterization of NP
Week 5 Gold NP for biomedical applications
Week 6 Magnetic NP for biomedical applications
Week 7 Quantum dots in biomedical applications
Assessment Due: Presentation *
Week 8 Midsemester break (no lecture)
Week 9 Gene delivery using NP
Week 10 Artificial cells using nanoparticles
Week 11 Nanoscale graphene in biomedical applications
Week 12 Nanoscale design in biomedical engineering
Week 13 Revision
Assessment Due: Assignment *
Exam Period Assessment Due: Final examination

Course Relations

The following is a list of courses which have added this Unit to their structure.

Course Year(s) Offered
Biomedical Mid-Year 2018, 2019, 2020
Biomedical/ Project Management 2019, 2020
Biomedical 2016, 2017, 2018, 2019, 2020
Biomedical / Arts 2019, 2020
Biomedical / Commerce 2019, 2020
Biomedical /Science 2019, 2020
Biomedical/Science (Health) 2019, 2020
Biomedical / Law 2019, 2020
Biomedical/Science (Medical Science Stream) 2019, 2020
Master of Engineering 2019, 2020
Master of Professional Engineering (Accelerated) (Biomedical) 2019, 2020
Master of Professional Engineering (Biomedical) 2019, 2020

Course Goals

This unit contributes to the achievement of the following course goals:

Attribute Practiced Assessed
(2) Engineering/ IT Specialisation (Level 3) Yes 26%
(3) Problem Solving and Inventiveness (Level 3) Yes 20%
(4) Design (Level 3) Yes 8%
(5) Interdisciplinary, Inclusiveness, Influence (Level 3) Yes 16%
(6) Communication and Inquiry/ Research (Level 2) Yes 26%
(8) Professional Effectiveness and Ethical Conduct (Level 2) Yes 4%

These goals are selected from Engineering & IT Graduate Outcomes Table 2018 which defines overall goals for courses where this unit is primarily offered. See Engineering & IT Graduate Outcomes Table 2018 for details of the attributes and levels to be developed in the course as a whole. Percentage figures alongside each course goal provide a rough indication of their relative weighting in assessment for this unit. Note that not all goals are necessarily part of assessment. Some may be more about practice activity. See Learning outcomes for details of what is assessed in relation to each goal and Assessment for details of how the outcome is assessed. See Attributes for details of practice provided for each goal.