Note: This unit version is currently under review and is subject to change!

BMET5962: Introduction to Mechanobiology (2019 - Semester 2)

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Unit: BMET5962: Introduction to Mechanobiology (6 CP)
Mode: Normal-Day
On Offer: Yes
Level: Postgraduate
Faculty/School: School of Aerospace, Mechanical & Mechatronic Engineering
Unit Coordinator/s: Dr RAMASWAMY, Yogambha
Session options: Semester 2
Versions for this Unit:
Campus: Camperdown/Darlington
Pre-Requisites: None.
Prohibitions: AMME5962.
Brief Handbook Description: Mechanobiology has emerged as a new field of science that integrates biology and engineering and is now considered to have significant influence on the development of technologies for regenerative medicine and tissue engineering. It is well known that tissues and cells are sensitive to their mechanical environment and changes to this environment can affect the physiological and pathophysiological processes. Understanding the mechanisms by which biological cells sense and respond to mechanical signals can lead to the development of novel treatments and therapies for a variety of diseases.

The objectives are:

a) To understand the basic principles of cell biology.

b) Learn to apply and integrate engineering principles to biological processes.

c) To understand the basic principles of mechanobiology and its importance in the field of tissue engineering and regenerative medicine

d) Understand the challenges and difficulties involved in the field of mechanobiology

e) Develop basic research skills in mechanobiology.
Assumed Knowledge: 6 credit points of 1000-level biology, 6 credit points of 1000-level chemistry and 6 credit points of 2000-level physiology or equivalent 
Lecturer/s: Dr RAMASWAMY, Yogambha
Timetable: BMET5962 Timetable
Time Commitment:
# Activity Name Hours per Week Sessions per Week Weeks per Semester
1 Lecture 2.00 1 13
2 Tutorial 2.00 1 12
3 Independent Study 5.00 13

Attributes listed here represent the key course goals (see Course Map tab) designated for this unit. The list below describes how these attributes are developed through practice in the unit. See Learning Outcomes and Assessment tabs for details of how these attributes are assessed.

Attribute Development Method Attribute Developed
Students will undertake analysis and discussion about the recent advances and the applications of various types of analytical methods used in the field of mechanobiology. (2) Engineering/ IT Specialisation (Level 3)
Students will get an exposure to various aspects of mechanobiology and give them an insight into how engineering principles can be integrated with the biological sciences and discuss these concepts through the discussion and problem solving activity (3) Problem Solving and Inventiveness (Level 3)
students will be introduced to the emerging and interdisciplinary field of mechanobiology. The students will learn and understand the importance of mechanics in biological sciences and the influence of mechanobiology in the field of tissue engineering and regenerative medicine. (5) Interdisciplinary, Inclusiveness, Influence (Level 3)
Students will learn to communicate, organise, question and analyse through the group presentation activity. (6) Communication and Inquiry/ Research (Level 3)

For explanation of attributes and levels see Engineering & IT Graduate Outcomes Table 2018.

Learning outcomes are the key abilities and knowledge that will be assessed in this unit. They are listed according to the course goal supported by each. See Assessment Tab for details how each outcome is assessed.

(6) Communication and Inquiry/ Research (Level 3)
1. Group presentations will enable the students to achieve effective oral communications skills, understanding research questions, critical analysis and data interpretation
2. To obtain information using appropriate search strategies to gain in-depth knowledge and current advances in mechanobiology through peer reviewed research resources
(4) Design (Level 3)
3. To understand the importance of applying engineering technologies for biomedical applications, Application of materials properties and design in the field of mechanobiology.
(2) Engineering/ IT Specialisation (Level 3)
4. Learn to apply and integrate engineering principles to biological processes.
5. To understand the basic principles of mechanobiology and its importance in the field of tissue engineering and regenerative medicine
Assessment Methods:
# Name Group Weight Due Week Outcomes
1 Presentation 1 Yes 5.00 Week 5 (Monday, 3 pm) 1, 2, 3, 4, 5,
2 Quiz 1 No 15.00 Week 6 (Monday, 3 pm) 1, 2, 3, 4, 5,
3 Presentation 2 Yes 15.00 Week 10 (Monday, 3 pm) 1, 2, 3, 4, 5,
4 Quiz 2 No 15.00 Week 12 (Monday, 3 pm) 1, 2, 3, 4, 5,
5 Tutorial activity No 10.00 Multiple Weeks (Monday, 3 pm) 1, 2, 3, 4, 5,
6 Final Exam No 40.00 Exam Period 3, 4, 5,
Assessment Description: Presentation/Seminar: A class presentation, on a topic of choice chosen at start of semester.

Quizzes will be held in the tutorials

Final Exam: 2 hour exam
Grading:
Grade Type Description
Standards Based Assessment Final grades in this unit are awarded at levels of HD for High Distinction, DI (previously D) for Distinction, CR for Credit, PS (previously P) for Pass and FA (previously F) for Fail as defined by University of Sydney Assessment Policy. Details of the Assessment Policy are available on the Policies website at http://sydney.edu.au/policies . Standards for grades in individual assessment tasks and the summative method for obtaining a final mark in the unit will be set out in a marking guide supplied by the unit coordinator.
Policies & Procedures: See the policies page of the faculty website at http://sydney.edu.au/engineering/student-policies/ for information regarding university policies and local provisions and procedures within the Faculty of Engineering and Information Technologies.

Note that the "Weeks" referred to in this Schedule are those of the official university semester calendar https://web.timetable.usyd.edu.au/calendar.jsp

Week Description
Week 1 Overview of Mechanobiology
Week 2 Mechanics of intracellular polymeric networks
Week 3 Cell signalling and mechanotransduction
Week 4 Overview of analytical methods in mechanobiology-I
Week 5 Overview of analytical methods in mechanobiology-II
Assessment Due: Presentation 1
Week 6 Role of biomaterials in mechanobiology
Assessment Due: Quiz 1
Week 7 Cell migration and the influence of mechanics
Week 8 Mechanosensitive ion channels 1
Week 9 Extracellular matrix mechanics
Week 10 Mechanosensitive ion channels-2
Assessment Due: Presentation 2
Week 11 Microfluidic devices in mechanobiology
Week 12 Mechanics in bone biology
Assessment Due: Quiz 2
Week 13 Mechanobiology: Current status, major advances and its future
Exam Period Assessment Due: Final Exam

Course Relations

The following is a list of courses which have added this Unit to their structure.

Course Year(s) Offered
Biomedical Mid-Year 2018, 2019, 2020
Biomedical/ Project Management 2019, 2020
Biomedical 2016, 2017, 2018, 2019, 2020
Biomedical / Arts 2019, 2020
Biomedical / Commerce 2019, 2020
Biomedical /Science 2019, 2020
Biomedical/Science (Health) 2019, 2020
Biomedical / Law 2019, 2020
Biomedical/Science (Medical Science Stream) 2019, 2020
Master of Engineering 2019, 2020
Master of Professional Engineering (Accelerated) (Biomedical) 2019, 2020
Master of Professional Engineering (Biomedical) 2019, 2020

Course Goals

This unit contributes to the achievement of the following course goals:

Attribute Practiced Assessed
(6) Communication and Inquiry/ Research (Level 3) Yes 25.5%
(5) Interdisciplinary, Inclusiveness, Influence (Level 3) Yes 0%
(4) Design (Level 3) No 25.6%
(3) Problem Solving and Inventiveness (Level 3) Yes 0%
(2) Engineering/ IT Specialisation (Level 3) Yes 48.9%

These goals are selected from Engineering & IT Graduate Outcomes Table 2018 which defines overall goals for courses where this unit is primarily offered. See Engineering & IT Graduate Outcomes Table 2018 for details of the attributes and levels to be developed in the course as a whole. Percentage figures alongside each course goal provide a rough indication of their relative weighting in assessment for this unit. Note that not all goals are necessarily part of assessment. Some may be more about practice activity. See Learning outcomes for details of what is assessed in relation to each goal and Assessment for details of how the outcome is assessed. See Attributes for details of practice provided for each goal.